Search results for " (AGE)"
showing 10 items of 23141 documents
Italica (Seville, Spain): use of local marble in Augustan age
2010
This study concerns 51 marble finds made of “Cipollino verde” coming from the ancient city of Italica (north of the modern city of Santiponce, 9 km NW of Seville, Spain), the earliest Roman settlement in Spain, founded in 206 B.C. The aim of this work was to determine their provenance from Greek and Italian quarries or from local quarries worked in the Iberian Peninsula. Thin-section optical microscopy, X-ray powder diffraction, bulk rock chemistry and O, C and Sr stable isotope analyses were carried out. Results were compared with literature data on “Cipollino verde” marbles quarried in southern Euboea (Greece), Apuan Alps (Italy), Almería, Extremoz, Seville (Spain) and Évora (Portugal). T…
Le refus d'intégration dans le corps de professeurs des écoles d'une institutrice non inspectée depuis seize ans !
2001
International audience
Predicting children's mathematical performance in grade one by early numeracy
2010
Abstract This longitudinal study examined how children's early numeracy assessed in kindergarten predicts their mathematical performance in the first grade, after controlling for the effects of age, gender, and parents' education. The participants were 212 Finnish children (107 girls and 105 boys). At the time of the first assessment (kindergarten), the mean age was six years, and the second assessment was conducted one year later. The results demonstrate that the acquisition of counting and relational skills before formal schooling are predictive of the acquisition of basic arithmetical skills and overall mathematical performance in grade one, above and beyond the effects of demographic fa…
New bronchodilators selected by molecular topology.
1998
Molecular topology has been applied to find new lead compounds with bronchodilator activity. Among the selected compounds stands out 3-(1H-tetrazol-5yl)-9H-thioxanthene-9 -one-10,10-dioxide, anthrarobin, 9-oxo-9H-thioxantene-3-carboxylic-10,10-dioxide acid, acenocoumarol and griseofulvin, with a percentage of relaxation, at 0.1 mM, of 91, 92, 85, 69, and 74%, respectively. Theophylline shows a correspondent value of 77% (Emax = 100% at 1 mM).
Synthesis, Anti-Inflammatory Activity, and in Vitro Antitumor Effect of a Novel Class of Cyclooxygenase Inhibitors: 4-(Aryloyl)phenyl Methyl Sulfones
2010
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These substances were characterized for their capacity to inhibit cyclooxygenase (COX-1 and COX-2) isoenzymes. Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms. The N-arylindole 33 was the most potent inhibitor of COX-2 and also the most selective (COX-1/COX-2 IC(50) ratio was 262). The indole derivative 33 was further tested in vivo for its ant…
Determinants of between-hospital variations in outcomes for patients admitted with COPD exacerbations: findings from a nationwide clinical audit (AUD…
2015
Background Previous studies have demonstrated significant variability in the processes of care and outcomes of chronic obstructive pulmonary disease (COPD) exacerbations. The AUDIPOC is a Spanish nationwide clinical audit that identified large between-hospital variations in care and clinical outcomes. Here, we test the hypothesis that these variations can be attributed to either patient characteristics, hospital characteristics and/or the so-called hospital-clustering effect, which indicates that patients with similar characteristics may experience different processes of care and outcomes depending on the hospital to which they are admitted. Methods A clinical audit of 5178 COPD patients co…
Dental anomalies in a Portuguese population
2013
The aim of this study was to evaluate the prevalence and pattern of agenesis, supernumerary teeth, impacted teeth and transpositions, as well as the relation between them, in a Portuguese sample.The study sample consisted of 2888 patients, observed between 2005 and 2009 at the Dentistry Clinic of the Instituto Superior de Ciências da Saúde-Norte (ISCSN, Portugal). The study included evaluation of the following parameters: agenesis of all teeth, supernumerary teeth, impacted permanent teeth and tooth transposition. The age range varied from 7 to 21 years. In order to study the absence of the third molar, subjects aged below 14 years were excluded. Statistical analysis was performed using SPS…
Les origines médiévales du « Ban de Laître » d’Augny, Moselle (fin du Xe – fin du XIVe s.)
2018
Le document est est téléchargeable ici :https://www.researchgate.net/publication/324702732_Les_origines_medievales_du_Ban_de_Laitre_d'Augny_Moselle_fin_du_Xe_-_fin_du_XIVe_s/related; International audience
The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma
2014
Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells d…
Analysis of relapse after transplantation in acute leukemia: A comparative on second allogeneic hematopoietic cell transplantation and donor lymphocy…
2018
Relapse of acute leukemia (AL) after allogeneic hematopoietic cell transplantation (Allo-HCT) entails a dismal prognosis. In this scenario, donor lymphocyte infusions (DLIs) and second Allo-HCT are two major approaches. We compared outcomes of AL patients treated for relapse with DLI or second Allo-HCT after receiving debulking therapy. In total, 46 patients were included in the study; 30 (65%) had acute myeloid leukemia and 16 (35%) had acute lymphoblastic leukemia. The median age was 38 years (range 4-66). Twenty-seven patients received a second Allo-HCT and 19 patients received DLI. The median follow-up of the cohort was 273 days (range 9-7013). Overall survival (OS), disease-free surviv…